Longitudinal ECG changes in cocaine users during extended abstinence

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Brain Structural and Functional Changes in Cocaine Users during Abstinence

Stimulant abuse, particularly cocaine abuse is an important public health concern, as according to 2013 National Survey on Drug Use and Health (SAMHSA, 2013) [1], there are 1.5 million current cocaine users in the United States and costs to the society for drug abuse including cocaine abuse are calculated to be $62 billion (NDCS, 1997) [2]. Utilizing brain imaging techniques and neuropsychologi...

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Extensive evidence indicates that current and recently abstinent cocaine abusers compared to drug-naïve controls have decreased grey matter in regions such as the anterior cingulate, lateral prefrontal and insular cortex. Relatively little is known, however, about the persistence of these deficits in long-term abstinence despite the implications this has for recovery and relapse. Optimized voxe...

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Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration.

Alterations in 5-HT1B receptor function during cocaine abstinence were evaluated in rats given either limited- or extended access (LA and EA, respectively) to cocaine self-administration. The locomotor response to the 5-HT1B/1A agonist RU24969 was significantly reduced in cocaine-experienced animals relative to cocaine-naïve controls following 6 h of abstinence but became sensitized over the su...

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This study examined sleep changes following cessation of marijuana and alcohol use during late adolescence. Twenty-nine heavy marijuana and alcohol users and 20 matched controls were studied during a 28-day monitored abstinence period. Sleep was examined as a function of prior substance use during Nights 1-2 and Nights 27-28. On Night 2, percent rapid eye movement sleep was predicted by past mo...

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ژورنال

عنوان ژورنال: Drug and Alcohol Dependence

سال: 2008

ISSN: 0376-8716

DOI: 10.1016/j.drugalcdep.2007.12.001